Progesterone
Progesterone is a natural female sex hormone (progestogen) essential for regulating ovulation, the menstrual cycle, and maintaining pregnancy. It is prescribed for hormone replacement therapy in menopause, treatment of menstrual disorders, prevention of endometrial hyperplasia during estrogen therapy, and support of fertility treatments.
Progesterone is a female hormone used to regulate reproductive functions, support pregnancy, and treat hormone-related conditions.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- G03DA04
- RxNorm
- 8727
- Generic
- Progesterone
- Class
- atc-g03
- Brands
- Eazi-Breed CIDR, Crinone, Synovex C, Bijuva, Synovex S, Prometrium, Endometrin
- Availability
- rx
- Pregnancy
- B
- Lactation
- safe
- Routes
- oral, vaginal, topical
- Forms
- capsule, gel, solution
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of menstrual irregularities and absent menstruation; hormone replacement therapy (HRT) in postmenopausal women to prevent endometrial hyperplasia; support of early pregnancy in fertility treatments; combined with estrogen in HRT regimens; treatment of endometriosis.
Progesterone binds to progesterone receptors in target tissues, including the uterus, breasts, and brain. It prepares and maintains the uterine lining (endometrium) for potential implantation, suppresses ovulation during pregnancy, thickens cervical mucus, and modulates the effects of estrogen on the endometrium when used in combination therapy.
Available in multiple formulations including oral capsules, vaginal gels/suppositories, and intramuscular injections. Should not be used during pregnancy unless specifically indicated for fertility support. May cause drowsiness, particularly with injectable forms. Transdermal formulations should be applied to the skin as directed. Contraindicated in patients with liver disease, unexplained vaginal bleeding, or known/suspected breast cancer. Different formulations have specific administration requirements and should not be used interchangeably without medical guidance.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy