Diazoxide
Proglycem (diazoxide) is a glucose-elevating medication primarily used to treat persistent hypoglycemia in infants, children, and adults with conditions causing dangerously low blood sugar such as hyperinsulinism, insulinomas, or nesidioblastosis. It works by inhibiting insulin secretion from the pancreas and promoting glucose release from the liver to raise blood sugar levels.
Proglycem is a blood glucose-raising medication used to treat chronic hypoglycemia caused by various pancreatic and metabolic disorders.
Key facts at a glance
- RxNorm
- 202595
- Generic
- Proglycem
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Proglycem is used to treat chronic hypoglycemia in patients with conditions including hyperinsulinism, insulinomas, and nesidioblastosis. It is commonly prescribed for neonates, infants, and children with persistent hypoglycemic conditions, as well as adults requiring management of hypoglycemia associated with certain pancreatic disorders.
Diazoxide, the active ingredient in Proglycem, works by opening ATP-sensitive potassium channels on pancreatic beta cells, which inhibits insulin secretion. This reduces glucose uptake by tissues while promoting hepatic glucose production through gluconeogenesis and glycogenolysis, thereby raising blood glucose levels.
Proglycem should be used under medical supervision with regular blood glucose monitoring. Common side effects may include fluid retention, increased hair growth (hypertrichosis), and gastrointestinal disturbances. It is typically reserved for cases where dietary management alone is insufficient to control hypoglycemia.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy