Tacrolimus
Prograf (tacrolimus) is a prescription immunosuppressant medication used primarily to prevent organ rejection in patients who have received kidney, liver, or heart transplants. It works by suppressing the body's immune system to prevent it from attacking the transplanted organ. This medication requires careful monitoring by healthcare providers due to its narrow therapeutic window and potential for serious side effects.
Prograf is an immunosuppressant used to prevent organ rejection in transplant patients, requiring close medical monitoring.
Key facts at a glance
- RxNorm
- 196463
- Generic
- Prograf
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prevention of organ rejection following kidney, liver, and heart transplants. It may be used in combination with other immunosuppressive medications.
Prograf is a calcineurin inhibitor that works by inhibiting T-lymphocyte activation, thereby suppressing the immune response that could otherwise attack and reject a transplanted organ.
Requires regular blood level monitoring to ensure therapeutic effectiveness while avoiding toxicity. Common side effects include tremor, headache, hypertension, and kidney function changes. Patients should avoid live vaccines and take precautions to reduce infection risk. grapefruit juice may increase drug levels and should be avoided.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy