Aldesleukin
Proleukin (aldesleukin) is a recombinant interleukin-2 immunotherapy used to treat certain cancers, specifically metastatic renal cell carcinoma and metastatic melanoma. It works by stimulating the body's immune system to attack cancer cells through activation of T-cells and natural killer cells. Due to its significant side effect profile, it is typically administered in specialized healthcare settings with close monitoring.
Proleukin is an immunotherapy drug used to treat certain metastatic kidney cancers and melanomas by stimulating the immune system to fight cancer.
Key facts at a glance
- RxNorm
- 203760
- Generic
- Proleukin
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Proleukin is FDA-approved for the treatment of adults with metastatic renal cell carcinoma (kidney cancer) and metastatic melanoma. Patient selection is important, as it is generally reserved for those with good organ function and performance status.
Proleukin is a recombinant form of interleukin-2 (IL-2), a naturally occurring cytokine. It works by binding to IL-2 receptors on immune cells, promoting the proliferation and activation of T-lymphocytes and natural killer (NK) cells, thereby enhancing the immune system's ability to recognize and destroy cancer cells.
Proleukin can cause serious adverse effects including capillary leak syndrome, severe hypotension, cardiac arrhythmias, neurotoxicity, and organ dysfunction. It requires administration in facilities experienced with its use and close monitoring of vital signs and organ function. Patients should be thoroughly evaluated before treatment, and those with pre-existing cardiac, pulmonary, hepatic, or renal impairment may not be suitable candidates.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy