Denosumab
Prolia is a brand-name medication that contains the active ingredient denosumab, a monoclonal antibody designed to treat bone-related conditions. It works by inhibiting a protein called RANKL, which is involved in bone breakdown. This medication is primarily used to treat osteoporosis and reduce fracture risk in specific patient populations.
Prolia is a prescription injection used to treat osteoporosis and bone loss by inhibiting bone breakdown.
Key facts at a glance
- RxNorm
- 993453
- Generic
- Prolia
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Postmenopausal women with osteoporosis at high risk for fractures; men with osteoporosis; men with bone loss from prostate cancer treatment; women with bone loss from breast cancer treatment; glucocorticoid-induced osteoporosis; giant cell tumor of bone.
Prolia is a monoclonal antibody that binds to RANKL (receptor activator of nuclear factor kappa-B ligand), blocking it from activating osteoclasts. This inhibits bone breakdown, increases bone density, and reduces fracture risk.
Given as a subcutaneous injection every 6 months. Can cause low blood calcium (hypocalcemia), especially in kidney disease patients. May increase risk of serious infections, jaw bone problems (osteonecrosis of the jaw), and unusual thigh bone fractures. Should not be used during pregnancy. Requires adequate vitamin D and calcium intake.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy