Promazine
Promazine is a first-generation antipsychotic medication belonging to the phenothiazine class, primarily used to manage symptoms of schizophrenia and other psychotic disorders. It may also be prescribed for severe agitation and anxiety when other treatments are not suitable. Due to its sedative properties, it has been utilized in psychiatric settings for acute management of agitated patients.
Promazine is an older antipsychotic used to treat schizophrenia and severe agitation by blocking dopamine activity in the brain.
Key facts at a glance
- ATC
- N05AA03
- RxNorm
- 8742
- Generic
- Promazine
- Class
- atc-n05
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- solution, tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Promazine is used to treat schizophrenia, psychotic disorders, and severe agitation or anxiety. It has also been used for management of nausea and vomiting in some cases.
Promazine works by blocking dopamine D2 receptors in the brain, which helps reduce psychotic symptoms. It also has anticholinergic and antihistamine effects that contribute to its sedative properties.
Promazine is an older antipsychotic with a higher risk of movement-related side effects compared to newer agents. It may cause drowsiness, dry mouth, and orthostatic hypotension. Use requires careful monitoring, and it is generally reserved for cases where newer antipsychotics are not appropriate or effective.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy