Promethazine
Promethegan (promethazine) is a first-generation antihistamine used to treat allergic reactions, nausea, vomiting, and motion sickness. It also provides sedation and is sometimes used as a sleep aid or preoperative sedative. This medication works by blocking histamine H1 receptors in the body, reducing allergic symptoms and suppressing nausea.
Promethegan is an antihistamine used for allergies, nausea, vomiting, and sedation.
Key facts at a glance
- RxNorm
- 219442
- Generic
- Promethegan
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Promethegan treats allergic conditions (hives, itching, allergic rhinitis), nausea and vomiting (including post-operative and motion-related), and is used for sedation and as a sleep aid.
It blocks histamine H1 receptors in the body, reducing allergic responses. It also has antiemetic and anticholinergic properties that help control nausea, vomiting, and motion sickness.
May cause significant drowsiness; avoid driving until you know how it affects you. Not recommended for children under 2 years due to risk of breathing problems. Can cause photosensitivity—use sun protection. Should be used cautiously in elderly patients. May interact with other sedating medications, alcohol, and certain antidepressants.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy