Prucalopride
Prucalopride is a prescription gastrointestinal prokinetic agent used to treat chronic constipation in adults who have not responded adequately to conventional laxative therapy.
A 5-HT4 receptor agonist that treats chronic constipation by stimulating colonic contractions to increase bowel motility.
Key facts at a glance
- ATC
- A06AX05
- RxNorm
- 2107310
- Generic
- Prucalopride
- Class
- atc-a06
- Brands
- Motegrity
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of chronic constipation in adults when standard laxative treatments (such as fiber supplements, osmotic or stimulant laxatives) have not provided adequate relief.
Prucalopride is a selective serotonin type 4 (5-HT4) receptor agonist. By activating these receptors in the gastrointestinal tract, it stimulates colonic peristalsis through high-amplitude propagating contractions (HAPCs), which accelerates transit through the colon and enhances bowel motility.
Prucalopride is typically prescribed as a second-line treatment after conventional laxatives have failed. Common side effects may include headache, abdominal pain, nausea, and diarrhea. It is contraindicated in patients with intestinal obstruction, perforation, or severe inflammatory conditions. A healthcare provider should evaluate cardiac history before initiating therapy, as rare cardiovascular effects have been reported.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy