Dornase Alfa
Pulmozyme (dornase alfa) is a recombinant enzyme administered via nebulizer that breaks down DNA in thick airway secretions. It is primarily prescribed for cystic fibrosis patients to reduce the frequency of respiratory infections and improve lung function by thinning mucus so it can be cleared more easily.
Pulmozyme is an inhaled mucolytic medication used by cystic fibrosis patients to thin and clear thick mucus from the airways.
Key facts at a glance
- RxNorm
- 74704
- Generic
- Pulmozyme
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of cystic fibrosis to reduce respiratory infections and improve pulmonary function by making airway secretions easier to clear.
Contains dornase alfa, a recombinant enzyme that hydrolyzes extracellular DNA in thick airway mucus, reducing viscosity and enabling easier clearance from the lungs.
Administered once daily via nebulizer; not for injection or oral use. May cause voice changes, throat irritation, rash, or chest discomfort. Effectiveness varies among patients. Pregnancy category B; consult a healthcare provider before use. Should be stored refrigerated and used within 24 hours of opening.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy