Bismuth Subcitrate Potassium
Pylera is a brand-name combination medication containing bismuth subsalicylate, metronidazole, and tetracycline. It is used alongside a proton pump inhibitor to treat Helicobacter pylori infection, a bacterial cause of peptic ulcers and gastritis.
Pylera is a triple-combination antibiotic used to eradicate H. pylori bacteria in patients with associated ulcers or gastritis.
Key facts at a glance
- RxNorm
- 705862
- Generic
- Pylera
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of Helicobacter pylori infection in patients with active duodenal ulcer or documented history of ulcer within the past year. It is used as part of combination therapy with a proton pump inhibitor.
The three components work together: bismuth subsalicylate damages H. pylori bacterial cell walls and has antimicrobial effects, while metronidazole and tetracycline are antibiotics that inhibit bacterial protein synthesis and DNA replication, collectively eradicating the infection.
Contraindicated during pregnancy, breastfeeding, and in children under 8 years old due to the tetracycline component. May cause dark discoloration of stool and tongue. Complete the full 10-14 day course as prescribed. Avoid alcohol during treatment due to metronidazole. Not for use as monotherapy.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy