Pyrazinamide
Pyrazinamide is an antibiotic medication used as a first-line treatment for tuberculosis (TB), typically administered during the initial intensive phase of multi-drug therapy alongside other antimycobacterial agents. It is a synthetic derivative of nicotinamide that exhibits bactericidal activity specifically against Mycobacterium tuberculosis.
Pyrazinamide is an antimycobacterial drug primarily used in combination therapy to treat tuberculosis infections.
Key facts at a glance
- ATC
- J04AK01
- RxNorm
- 8987
- Generic
- Pyrazinamide
- Class
- atc-j04
- Brands
- —
- Availability
- rx
- Pregnancy
- C
- Lactation
- caution
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Pyrazinamide is indicated for the treatment of active pulmonary and extrapulmonary tuberculosis as part of a multi-drug regimen. It is particularly used during the intensive phase of TB therapy, often in combination with isoniazid, rifampin, and/or ethambutol.
Pyrazinamide is a prodrug that is converted by Mycobacterium tuberculosis to its active form, pyrazinoic acid. The exact mechanism is not fully understood but is believed to involve disruption of bacterial fatty acid synthesis, energy production, and membrane transport function, leading to inhibition of bacterial growth.
Pyrazinamide can cause hepatotoxicity and requires regular monitoring of liver function tests. Hyperuricemia is a common side effect due to inhibition of renal uric acid excretion. It is generally avoided in patients with severe hepatic impairment and should be used with caution during pregnancy.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy