Rabeprazole
Rabeprazole is a proton pump inhibitor that reduces stomach acid by blocking the gastric H+, K+ ATPase enzyme.
Rabeprazole is a proton pump inhibitor that suppresses stomach acid production to treat acid-related conditions like GERD and ulcers.
Key facts at a glance
- ATC
- A02BC04
- RxNorm
- 114979
- Generic
- Rabeprazole
- Class
- atc-a02
- Brands
- Aciphex
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of gastroesophageal reflux disease (GERD), including erosive esophagitis; healing and maintenance of peptic ulcers; treatment of Zollinger-Ellison syndrome; and as part of combination therapy for Helicobacter pylori eradication in patients with peptic ulcer disease.
As a substituted benzimidazole proton pump inhibitor, rabeprazole irreversibly inhibits the gastric H+, K+ ATPase (proton pump) in parietal cells, blocking the final step of acid secretion into the stomach lumen.
Should be taken before meals, typically before breakfast. May reduce absorption of certain drugs like ketoconazole or iron salts. Long-term use may increase risk of bone fractures, B12 deficiency, and C. difficile infection. Generally well tolerated with common side effects including headache, diarrhea, and nausea.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy