Rabies Immune Globulin
Rabies Immune Globulin (Human) is a blood product containing antibodies against the rabies virus, used as part of post-exposure prophylaxis after potential rabies exposure such as animal bites or scratches. It provides immediate passive immunity while the rabies vaccine stimulates the body to develop its own protective antibodies. This medication is administered once, typically alongside the first dose of rabies vaccine.
A passive immunization product providing immediate rabies protection when combined with vaccine after suspected exposure.
Key facts at a glance
- ATC
- J06BB05
- RxNorm
- 89886
- Generic
- Rabies Immune Globulin, Human
- Class
- atc-j06
- Brands
- Imogam, Kedrab, HyperRAB
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- injection
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 20 IU/kg body weight (maximum 1500-2000 IU)
- Maximum
- consult physician
- Frequency
- single dose, preferably within 24 hours of exposure
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 20 IU/kg body weight
- Maximum
- consult physician
- Frequency
- single dose, preferably within 24 hours of exposure
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
6 groupspregnancy
all trimestersno specific adjustment
use when benefits outweigh risks; rabies postexposure prophylaxis is not contraindicated during pregnancy
standard prenatal monitoring
Use with caution and monitor for adverse effects.
lactation
breastfeedingno adjustment needed
compatible with breastfeeding; continue breastfeeding after administration
none specific
pediatric_age
neonates infantsdose based on weight (20 IU/kg) same as adults
can be administered to children of all ages including infants; no age restrictions
standard pediatric monitoring
geriatric
elderlyno specific adjustment; use standard weight-based dosing
can be used in elderly patients; no dosage modification required
standard geriatric monitoring
renal_impairment
severeno specific adjustment; monitor renal function
use with caution in patients with severe renal impairment; monitor for infusion reactions
monitor renal function and for signs of infusion reaction
Use with caution and monitor for adverse effects.
hepatic_impairment
severeno specific adjustment needed
can be used in patients with hepatic impairment; no dosage modification required
standard hepatic function monitoring
Statistics and clinical data
First FDA approval
Historical FDA approval timeline for rabies immune globulin products
Drug class
Biological product classification
Primary indication
Primary therapeutic use when administered with rabies vaccine
Dosing approach
Standard recommended dose for post-exposure prophylaxis
Post-exposure prophylaxis against rabies in individuals exposed to potentially rabid animals, including bites, scratches, or other contact that may transmit the rabies virus. It is used when the exposure warrants both immune globulin and vaccination series.
Contains concentrated antibodies (immunoglobulins) that recognize and neutralize rabies virus at the wound site and in the bloodstream. This provides immediate but temporary protection while the rabies vaccine induces longer-lasting active immunity.
Should be administered as soon as possible after exposure, ideally with the first vaccine dose. Infiltrated around the wound site when anatomically feasible, with any remainder given intramuscularly at a different site. Patients with severe allergies to immunoglobulin products or certain bleeding disorders may require special consideration. Not a substitute for the rabies vaccine series.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 24, 2026. · Read our editorial policy