Racecadotril
Racecadotril is an antidiarrheal medication that reduces intestinal fluid secretion by inhibiting the enzyme enkephalinase, which increases natural opioid activity in the gut lining.
Racecadotril is an antidiarrheal that reduces intestinal secretion by enhancing natural opioid activity in the gut.
Key facts at a glance
- ATC
- A07XA04
- RxNorm
- 16738
- Generic
- Racecadotril
- Class
- atc-a07
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of acute diarrhea in adults and children. It is used as part of oral rehydration therapy to reduce the duration and severity of diarrheal episodes, particularly in cases of acute gastroenteritis.
Racecadotril is a pro-drug that inhibits enkephalinase in the intestinal mucosa. This enzyme normally degrades enkephalins (endogenous opioid peptides). By preventing this breakdown, racecadotril increases enkephalin levels, which inhibits intestinal secretion of water and electrolytes while preserving normal intestinal motility.
Racecadotril is generally well-tolerated with a good safety profile. It does not cause constipation like typical opioid antidiarrheals. Treatment should begin at the first sign of diarrhea with a loading dose followed by maintenance doses. Adequate fluid and electrolyte replacement remains essential. Not typically used for chronic diarrhea or antibiotic-associated diarrhea. Common side effects may include headache and skin reactions.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy