Raloxifene
Raloxifene is a selective estrogen receptor modulator (SERM) that acts as an estrogen agonist in bone tissue while acting as an antagonist in breast and uterine tissue. It is primarily used to prevent and treat osteoporosis in postmenopausal women and to reduce the risk of invasive breast cancer in high-risk patients.
A selective estrogen receptor modulator used for osteoporosis treatment and breast cancer risk reduction in postmenopausal women.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- G03XC01
- RxNorm
- 72143
- Generic
- Raloxifene
- Class
- atc-g03
- Brands
- Evista
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prevention and treatment of postmenopausal osteoporosis; reduction of risk for invasive breast cancer in postmenopausal women with osteoporosis or at high risk for breast cancer.
Binds to estrogen receptors throughout the body, acting as an estrogen agonist in bone (increasing bone mineral density) and as an antagonist in breast and uterine tissue (blocking estrogen-mediated growth).
Not indicated for use in premenopausal women or men. Contraindicated in patients with active or history of venous thromboembolism, hepatic impairment, or unexplained uterine bleeding. May cause hot flashes. Does not stimulate the endometrium.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy