Ranolazine
Ranexa (ranolazine) is a prescription medication used to treat chronic angina (chest pain) in adults. It is typically used when other heart medications have not adequately controlled symptoms. This medication is not a first-line treatment and is usually added to an existing angina management regimen.
Ranexa is an anti-anginal medication used to treat chronic chest pain in adults when other treatments are insufficient.
Key facts at a glance
- RxNorm
- 356778
- Generic
- Ranexa
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Ranexa is indicated for the treatment of chronic angina in adults. It is used when initial therapy with other anti-anginal medications (such as beta-blockers, calcium channel blockers, or nitrates) is not providing adequate symptom control. It is not intended for acute episodes of chest pain.
Ranexa works by partially inhibiting the late inward sodium current in cardiac cells during the action potential. This reduces intracellular sodium and calcium accumulation, which decreases cardiac wall tension and oxygen demand during ischemic conditions. It also may improve coronary blood flow, helping to reduce angina symptoms.
Ranexa should be taken exactly as prescribed, typically twice daily with or without food. Common side effects may include dizziness, headache, constipation, and nausea. It can cause QT prolongation and should be used with caution in patients with liver impairment. Patients should avoid grapefruit juice while taking this medication. Ranexa is not a cure for heart disease and does not reduce the risk of heart attack.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy