Sirolimus
Rapamune (sirolimus) is an immunosuppressant medication primarily used to prevent organ rejection in patients who have received kidney transplants. It works by inhibiting the activation and proliferation of certain immune cells that could attack transplanted organs. The medication is typically used in combination with other immunosuppressive drugs and requires regular blood level monitoring.
Rapamune is an immunosuppressant used to prevent organ rejection following kidney transplantation.
Key facts at a glance
- RxNorm
- 258355
- Generic
- Rapamune
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prevention of organ rejection in kidney transplant recipients; also used for the treatment of lymphangioleiomyomatosis (LAM), a rare progressive lung disease.
Rapamune inhibits the mammalian target of rapamycin (mTOR), a key protein that regulates cell growth and division. By blocking this pathway, it prevents the activation and proliferation of T-cells and other immune cells that could attack a transplanted organ.
Requires regular blood level monitoring to maintain therapeutic range and prevent toxicity; may increase susceptibility to infections and certain cancers due to immunosuppression; common side effects include mouth ulcers, rash, elevated cholesterol, and swelling. Patients should avoid receiving live vaccines while taking this medication.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy