Fibrin Sealant
Raplixa is a topical fibrin sealant used during surgical procedures to help control mild to moderate bleeding. It contains human fibrinogen and thrombin, which work together to form a fibrin clot at the surgical site to promote hemostasis.
A topical hemostatic agent used during surgery to help control bleeding by forming a fibrin clot.
Key facts at a glance
- RxNorm
- 1655050
- Generic
- Raplixa
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Raplixa is indicated as a topical hemostatic agent to control mild to moderate bleeding during surgical procedures when standard surgical techniques are insufficient.
Raplixa contains human fibrinogen and human thrombin. When combined at the surgical site, thrombin converts fibrinogen to fibrin, which cross-links to form a stable fibrin clot that seals the bleeding tissue.
Raplixa is for topical use only and must not be applied intravascularly. It should not be used for severe arterial or brisk venous bleeding. There is a risk of infection transmission from human plasma components and potential for allergic reactions. Dosage depends on the size of the surgical area and severity of bleeding.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy