Calcifediol
Rayaldee is a brand-name extended-release vitamin D analog used to treat secondary hyperparathyroidism in adults with chronic kidney disease (CKD) stages 3 or 4. It contains the prohormone calcifediol, which is converted by the liver to active vitamin D to help regulate calcium and phosphorus metabolism.
Rayaldee treats secondary hyperparathyroidism in chronic kidney disease patients by providing a vitamin D precursor that raises 25-hydroxyvitamin D levels.
Key facts at a glance
- RxNorm
- 1855067
- Generic
- Rayaldee
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of secondary hyperparathyroidism in adults with CKD stage 3 or 4 (non-dialysis dependent)
Rayaldee contains calcifediol, a vitamin D3 prohormone that is converted in the liver to calcitriol (active vitamin D), which increases serum 25-hydroxyvitamin D levels, helps regulate calcium and phosphorus absorption, and suppresses parathyroid hormone (PTH) secretion
Should not be used with other vitamin D supplements or calcium-based phosphate binders; requires regular monitoring of serum calcium, phosphorus, and PTH levels; may cause hypercalcemia; contraindicated in patients with hypercalcemia or vitamin D toxicity
Official drug label
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Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy