Luspatercept
Reblozyl is an erythroid maturation agent used to treat anemia in adults with beta-thalassemia requiring regular red blood cell transfusions and in adults with very low- to intermediate-risk myelodysplastic syndromes (MDS) who have not responded to prior erythropoiesis-stimulating agents. It works by binding to TGF-beta superfamily ligands to promote late-stage red blood cell maturation and production.
Reblozyl is used to treat anemia in beta-thalassemia and certain MDS patients by promoting red blood cell maturation.
Key facts at a glance
- RxNorm
- 2262907
- Generic
- Reblozyl
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of anemia in adults with beta-thalassemia requiring regular red blood cell transfusions, and treatment of anemia in adults with very low- to intermediate-risk myelodysplastic syndromes (MDS) who have not responded adequately to prior erythropoiesis-stimulating agents and require regular RBC transfusions.
Reblozyl is an erythroid maturation agent that binds to certain TGF-beta superfamily ligands, reducing Smad2/3 signaling and promoting late-stage erythroid differentiation to increase red blood cell production.
Administered as a subcutaneous injection. Not a substitute for emergency RBC transfusions. May increase risk of thrombosis. Discontinue use if severe hypersensitivity reactions occur. Use with caution during pregnancy and breastfeeding. Common side effects include fatigue, headache, musculoskeletal pain, and dizziness.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy