Nitroglycerin
Rectiv is a topical brand-name medication containing nitroglycerin that is applied rectally to treat pain associated with chronic anal fissures. It works by releasing nitric oxide, which causes smooth muscle relaxation in the anal region, reducing sphincter spasms and allowing fissures to heal. This medication is typically used when conservative treatments have not provided adequate relief.
Rectiv is a nitroglycerin ointment used topically to relieve pain from chronic anal fissures by relaxing anal smooth muscle.
Key facts at a glance
- RxNorm
- 1114467
- Generic
- Rectiv
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Rectiv is indicated for the treatment of moderate to severe pain associated with chronic anal fissures (tears in the anal lining lasting 6 weeks or more) that have not responded to conservative treatments like dietary fiber supplements and stool softeners.
Rectiv contains nitroglycerin (0.4%), a nitrate that releases nitric oxide when absorbed. Nitric oxide activates guanylate cyclase in smooth muscle cells, increasing cyclic GMP levels, which leads to smooth muscle relaxation. In the anal region, this relaxes the internal anal sphincter, reducing spasm, decreasing pressure, and improving blood flow to promote fissure healing.
Rectiv is for rectal use only and should be applied with a finger covering or applicator as directed by a healthcare provider. Common side effects may include headache, dizziness, and rectal discomfort. Use with caution in patients taking phosphodiesterase inhibitors (e.g., sildenafil), as severe hypotension may occur. Avoid use in severe anemia, recent head trauma, or increased intracranial pressure. Treatment courses are typically limited to 3 weeks.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy