Tretinoin
Refissa is a brand-name topical medication containing tretinoin, a retinoid derivative of vitamin A. It is primarily used for the treatment of acne vulgaris and may also be prescribed to improve the appearance of fine wrinkles, rough skin texture, and hyperpigmentation associated with photodamage.
Refissa is a topical tretinoin cream used to treat acne and improve skin texture and signs of photodamage.
Key facts at a glance
- RxNorm
- 855680
- Generic
- Refissa
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Refissa is indicated for the topical treatment of acne vulgaris. It may also be used to address fine facial wrinkles, mottled hyperpigmentation, and rough skin texture associated with sun-damaged skin.
As a retinoid, Refissa promotes cellular turnover and helps normalize the shedding of skin cells within hair follicles, which can reduce the formation of comedones (blackheads and whiteheads) and improve overall skin texture.
Refissa may cause skin irritation, redness, and increased sensitivity to sunlight. Patients should use sunscreen and limit sun exposure during treatment. It is typically applied once daily to affected areas and may take several weeks to see improvement. Use during pregnancy should be avoided. Avoid contact with eyes, mouth, and mucous membranes.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy