Evolocumab
Repatha (evolocumab) is a prescription medication used to treat high cholesterol in adults and some children. It belongs to a class of drugs called PCSK9 inhibitors and is typically prescribed when statins alone are not sufficient to control cholesterol levels. This injectable medication helps reduce the risk of cardiovascular events in certain high-risk patients.
Repatha is an injectable cholesterol-lowering medication for patients who need additional LDL reduction beyond statin therapy.
Key facts at a glance
- RxNorm
- 1665896
- Generic
- Repatha
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Repatha is used to treat adults and children (ages 10 and older) with heterozygous familial hypercholesterolemia (HeFH) or clinical atherosclerotic cardiovascular disease who require additional LDL cholesterol lowering. It is also used in patients with homozygous familial hypercholesterolemia (HoFH).
Repatha is a monoclonal antibody that binds to and inhibits the PCSK9 protein. By blocking PCSK9, the medication allows more LDL receptors to remain active on liver cells, enabling the liver to remove more LDL cholesterol from the bloodstream, thereby lowering LDL levels.
Repatha is administered as a subcutaneous injection (under the skin) once every 2 weeks or once monthly. Common side effects may include injection site reactions, upper respiratory tract symptoms, and flu-like symptoms. Patients should inform their healthcare provider of all medications and allergies before starting treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy