Repotrectinib
Repotrectinib is a targeted cancer therapy that inhibits ROS1 and TRK tyrosine kinases, proteins that when mutated or fused can drive tumor growth. It is prescribed for patients with cancers harboring ROS1 or NTRK gene fusions, such as certain types of non-small cell lung cancer and other solid tumors.
Repotrectinib is a targeted therapy for cancers with ROS1 or NTRK gene fusions that blocks signals promoting tumor growth.
Key facts at a glance
- ATC
- L01EX28
- RxNorm
- 2670644
- Generic
- Repotrectinib
- Class
- atc-l01
- Brands
- Augtyro
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- capsule
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Repotrectinib is indicated for the treatment of adults with ROS1-positive metastatic non-small cell lung cancer and for adult and pediatric patients with NTRK gene fusion-positive solid tumors who have progressed following treatment or have no satisfactory alternatives.
Repotrectinib works by inhibiting ROS1 and TRK (TRKA, TRKB, TRKC) tyrosine kinases—proteins involved in cell growth and survival. Gene fusions involving ROS1 or NTRK can cause these kinases to be constitutively active, leading to uncontrolled cancer cell proliferation. By blocking this activity, repotrectinib slows tumor growth.
Repotrectinib is a specialized targeted therapy requiring biomarker testing to confirm ROS1 or NTRK fusion status before treatment. Common side effects may include dizziness, fatigue, and neurological effects. Patients should be monitored by an oncologist and advised not to drive if experiencing significant dizziness or coordination problems.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy