Hydrocodone
Reprexain is a prescription combination medication containing hydrocodone (an opioid) and ibuprofen (an NSAID). It is used for the management of moderate to severe pain in adults who require an opioid pain reliever and an NSAID. The medication works through two mechanisms: the opioid component binds to receptors in the brain to reduce pain perception, while the NSAID reduces inflammation and provides additional pain relief.
Reprexain is a prescription opioid-NSAID combination used for short-term management of moderate to severe pain.
Key facts at a glance
- RxNorm
- 579458
- Generic
- Reprexain
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Reprexain is indicated for the short-term (generally less than 10 days) management of acute, moderate to severe pain in adults. It is typically prescribed when other pain management options are insufficient.
Reprexain combines two active ingredients: hydrocodone, an opioid agonist that binds to opioid receptors in the brain and spinal cord to alter pain perception, and ibuprofen, an NSAID that inhibits cyclooxygenase (COX) enzymes to reduce inflammation, fever, and pain.
Reprexain is a Schedule II controlled substance with significant risks of addiction, abuse, and misuse. The ibuprofen component carries warnings for gastrointestinal bleeding, cardiovascular events, and kidney problems. It should not be used in children post-operatively and is typically reserved for short-term use. Patients should follow dosing instructions carefully and avoid alcohol due to increased risk of serious adverse effects.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy