Reserpine
Reserpine is an older antihypertensive medication derived from the rauwolfia plant that works by depleting catecholamine neurotransmitters from nerve terminals. It was historically used to treat hypertension and occasionally certain psychiatric conditions, though its use has declined significantly due to side effects. Currently, it is rarely prescribed as a first-line agent for high blood pressure.
Reserpine is an older blood pressure medication that depletes neurotransmitters to lower blood pressure, now rarely used due to newer, safer alternatives.
Key facts at a glance
- ATC
- C02AA02
- RxNorm
- 9260
- Generic
- Reserpine
- Class
- atc-c02
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Reserpine is primarily used for treating hypertension (high blood pressure). Historically, it was also used for certain psychiatric conditions including psychosis and anxiety, though these applications have largely been abandoned in modern practice.
Reserpine works by irreversibly inhibiting the vesicular monoamine transporter (VMAT), which prevents the storage and release of catecholamines (norepinephrine, epinephrine) and serotonin from nerve terminals. This depletion of neurotransmitters leads to decreased sympathetic nervous system activity, resulting in reduced blood pressure and heart rate.
Common side effects include sedation, depression, nasal congestion, and gastrointestinal disturbances. Due to its side effect profile, particularly concerns about depression and suicidality, reserpine is rarely used as first-line therapy. It may interact with other medications affecting the central nervous system. Patients should be monitored for signs of depression and should not discontinue abruptly.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy