Resmetirom
Resmetirom is a selective thyroid hormone receptor beta (THR-β) agonist used for treating nonalcoholic steatohepatitis (NASH), a condition now referred to as metabolic dysfunction-associated steatohepatitis.
Resmetirom is a liver-targeted therapy for MASH/NASH that works by activating thyroid hormone receptors to reduce liver fat and inflammation.
Key facts at a glance
- ATC
- A05BA11
- RxNorm
- 2677894
- Generic
- Resmetirom
- Class
- atc-a05
- Brands
- Rezdiffra
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of nonalcoholic steatohepatitis (NASH)/metabolic dysfunction-associated steatohepatitis (MASH) with fibrosis in adults.
Resmetirom is a selective thyroid hormone receptor beta (THR-β) agonist. It activates THR-β receptors in the liver, which promotes hepatic fat metabolism, reduces lipotoxicity, decreases liver inflammation, and may improve fibrosis.
Resmetirom is an oral medication. Liver function monitoring may be required during treatment. Patients should be counseled on potential side effects, which may include gastrointestinal symptoms. Contraindications and specific usage restrictions should be reviewed based on prescribing information.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy