Reteplase
Retavase is a brand-name thrombolytic medication containing reteplase, used to dissolve dangerous blood clots in patients experiencing acute myocardial infarction (heart attack). It works by activating plasminogen to plasmin, an enzyme that breaks down fibrin in blood clots, helping to restore blood flow to the heart muscle. This medication is typically administered as an intravenous double-bolus injection in hospital emergency settings.
Retavase is an emergency thrombolytic medication used to dissolve blood clots during acute heart attacks.
Key facts at a glance
- RxNorm
- 219642
- Generic
- Retavase
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Retavase is indicated for the treatment of acute myocardial infarction (AMI) in adults, helping to reduce mortality associated with heart attacks when administered promptly after symptom onset, particularly when percutaneous coronary intervention is not immediately available.
Retavase contains reteplase, a recombinant tissue plasminogen activator (tPA) that converts plasminogen to plasmin. Plasmin then breaks down fibrin in blood clots, dissolving the clot and restoring blood flow through blocked coronary arteries.
Retavase should only be used in hospital settings with appropriate monitoring. It is contraindicated in patients with active bleeding, history of stroke, or recent surgery. Major risks include bleeding complications and allergic reactions. Efficacy is time-dependent, with earlier administration generally producing better outcomes.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy