Reteplase
Reteplase is a recombinant thrombolytic agent used to dissolve harmful blood clots in patients experiencing acute myocardial infarction. It works by activating plasminogen to plasmin, which breaks down fibrin strands that hold blood clots together. This medication is administered as an IV double-bolus injection, typically within 12 hours of heart attack symptom onset.
Reteplase is a clot-dissolving medication used to treat acute heart attacks by breaking down blood clots blocking coronary arteries.
Key facts at a glance
- ATC
- B01AD07
- RxNorm
- 76895
- Generic
- Reteplase
- Class
- atc-b01
- Brands
- Retavase
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- injection
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of acute myocardial infarction (heart attack) to reduce mortality and preserve heart muscle function when administered within 12 hours of symptom onset.
Reteplase is a genetically engineered tissue plasminogen activator (tPA) that converts plasminogen to plasmin. Plasmin then breaks down fibrin, the structural framework of blood clots, restoring blood flow through occluded coronary arteries.
Must be given as early as possible for maximum benefit. Carries significant bleeding risk, especially intracranial hemorrhage. Contraindicated in active bleeding, recent surgery, history of stroke, and uncontrolled hypertension. Requires careful patient selection and monitoring.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy