Acellular Dermal Matrix
Rethymic is an allogeneic cultured thymus tissue-derived product used for immune reconstitution in pediatric patients with congenital athymia, most commonly associated with complete DiGeorge anomaly (22q11.2 deletion syndrome). This tissue-based therapy provides a functional thymic microenvironment to support the development and maturation of naive T-cells, addressing the severe immunodeficiency characteristic of this rare genetic condition.
Rethymic is a thymus tissue transplantation medication used to restore immune function in children born without a functioning thymus gland.
Key facts at a glance
- RxNorm
- 2626465
- Generic
- Rethymic
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Rethymic is indicated for immune reconstitution in pediatric patients with congenital athymia due to complete DiGeorge anomaly (22q11.2 deletion syndrome). It is specifically approved for patients who have no functional thymic tissue and require immune system restoration.
Rethymic consists of cultured human thymus tissue from donor organs. When surgically implanted, it provides a functional thymic microenvironment that allows the patient's bone marrow-derived T-cell progenitors to migrate, mature, and exit as educated, naive T-cells capable of mounting adaptive immune responses.
Rethymic is derived from allogeneic donor tissue and carries risks including potential immune rejection and graft-versus-host reactions. It requires surgical implantation and patients must be monitored long-term for immune reconstitution. This is typically a one-time treatment. Close clinical follow-up is essential to assess T-cell recovery and manage any adverse events.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy