Revumenib
Revumenib is a first-in-class menin inhibitor used to treat adults and children with relapsed or refractory acute myeloid leukemia (AML) that has KMT2A rearrangements or NPM1 mutations. It works by blocking the interaction between menin and KMT2A proteins, which are involved in driving these specific types of leukemia.
Revumenib is a targeted therapy for certain acute myeloid leukemias that inhibits the menin-KMT2A interaction.
This medication carries a boxed (black box) warning — the strongest type of FDA warning. Review the full prescribing information before use.
Key facts at a glance
- ATC
- L01XX87
- RxNorm
- 2698325
- Generic
- Revumenib
- Class
- atc-l01
- Brands
- Revuforj
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Revumenib is indicated for the treatment of adult and pediatric patients with relapsed or refractory acute myeloid leukemia (AML) with KMT2A translocations or NPM1 mutations.
As a menin inhibitor, Revumenib blocks the binding of wild-type KMT2A and KMT2A fusion proteins with menin, disrupting protein interactions that promote leukemia cell growth and survival.
Revumenib may cause differentiation syndrome, QT prolongation, and embryo-fetal toxicity. Regular monitoring of ECG and electrolytes is recommended during treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy