Brexpiprazole
Rexulti (brexpiprazole) is an atypical antipsychotic medication used to treat major depressive disorder as an adjunct therapy and schizophrenia in adults. It works by modulating dopamine and serotonin activity in the brain, helping to regulate mood and reduce psychotic symptoms.
Rexulti is a prescription antipsychotic used for depression and schizophrenia that works by balancing dopamine and serotonin in the brain.
Key facts at a glance
- RxNorm
- 1658320
- Generic
- Rexulti
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Rexulti is FDA-approved as an adjunct treatment for major depressive disorder and for the treatment of schizophrenia in adults. It may also be used off-label for other conditions as determined by a healthcare provider.
Rexulti is an atypical antipsychotic that works as a partial agonist at dopamine D2 and D3 receptors and serotonin 5-HT1A receptors, while also antagonizing 5-HT2A receptors. This modulation of neurotransmitter activity helps regulate mood, cognition, and psychotic symptoms.
Rexulti is available only as a brand-name medication (no generic equivalent). It carries a boxed warning that antipsychotics increase mortality risk in elderly patients with dementia-related psychosis. Common side effects may include weight gain, akathisia, and sedation. Patients should avoid alcohol and inform their doctor of any medical history of diabetes, seizures, or cardiovascular conditions before starting treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy