Dexamethasone
Rezdiffra is a prescription medication used to treat adults with metabolic dysfunction-associated steatohepatitis (MASH), a serious form of fatty liver disease, who have moderate to advanced liver scarring (fibrosis). It is the first FDA-approved drug specifically indicated for this condition and is used alongside diet and exercise.
Rezdiffra is a once-daily oral medication approved to treat MASH with moderate to advanced fibrosis by targeting thyroid hormone receptors in the liver.
Key facts at a glance
- RxNorm
- 2677900
- Generic
- Rezdiffra
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Rezdiffra is indicated for the treatment of noncirrhotic MASH with moderate to advanced liver fibrosis in adults. It should be used alongside a healthy diet and exercise program.
Rezdiffra contains the active ingredient resmetirom, which is a thyroid hormone receptor beta (THR-β) agonist. It works by activating THR-β receptors in the liver, which helps reduce liver fat accumulation, inflammation, and fibrosis associated with MASH.
Rezdiffra is available only through a restricted program called the Rezdiffra REMS Program. Common side effects may include diarrhea, nausea, and itching. Patients should have liver function monitored during treatment. It is not recommended for patients with decompensated cirrhosis. Rezdiffra may interact with certain medications, including some statins and thyroid hormones.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy