Rho(D) Immune Globulin
Rho(D) Immune Globulin is a blood product containing antibodies against the Rh(D) antigen on red blood cells. It is primarily administered to Rh-negative pregnant women who have been exposed to Rh-positive fetal blood to prevent sensitization and hemolytic disease of the fetus and newborn. This medication may also be given after incompatible blood transfusions in Rh-negative patients.
A passive antibody preparation used to prevent Rh sensitization in Rh-negative individuals exposed to Rh-positive blood.
Key facts at a glance
- ATC
- J06BB01
- RxNorm
- 35465
- Generic
- Rho(D) Immune Globulin
- Class
- atc-j06
- Brands
- RhoGAM, MICRhoGAM, WinRho, Rhophylac, HyperRHO
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- injection, prefilled syringe, solution
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Dosage and administration
- Usual dose
- 500mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 250mg twice daily
- Maximum
- consult physician
- Frequency
- every 12 hours
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
- Usual dose
- 400mg daily
- Maximum
- consult physician
- Frequency
- once daily
- Instructions
- Follow physician instructions
- Duration limits
- as prescribed
- Monitoring
- standard
Overdose information
Special Populations
7 groupspregnancy
first trimesteruse only after miscarriage, ectopic pregnancy, or trauma
administer within 72 hours of potential fetomaternal hemorrhage
monitor for signs of infection
Use with caution and monitor for adverse effects.
pregnancy
second third trimesterstandard dosing at 28 weeks gestation
standard dose of 300 mcg (3000 IU) IM at 28 weeks, repeat within 72 hours after delivery if infant is Rh-positive
routine prenatal monitoring
lactation
breastfeedingno adjustment needed
compatible with breastfeeding
none required
geriatric
elderlystandard adult dosing
use standard dosing for postpartum prophylaxis or trauma
standard monitoring
pediatric_age
childrenweight-based dosing for ITP
used for immune thrombocytopenic purpura at 250 mcg/kg for initial dose
monitor platelet count and for hemolysis
renal_impairment
renal failureuse with caution in severe renal impairment
monitor renal function; avoid rapid IV infusion
monitor renal function tests
Use with caution and monitor for adverse effects.
hepatic_impairment
severe hepatic impairmentno specific adjustment required
standard dosing may be used
standard monitoring
Statistics and clinical data
Commonly prescribed since
General prescribing information
Drug class
Drug class information
Common uses
Common therapeutic uses
Prevention of Rh(D) isoimmunization in Rh-negative pregnant women exposed to Rh-positive fetal blood through childbirth, abortion, amniocentesis, chorionic villus sampling, or trauma; prevention of Rh(D) sensitization after incompatible blood transfusions to Rh-negative recipients.
Provides passive IgG anti-Rh(D) antibodies that bind to Rh-positive red blood cells, preventing the Rh-negative recipient's immune system from recognizing and mounting an active immune response (sensitization) against the Rh(D) antigen.
Administered by intramuscular or intravenous injection. Must be given within 72 hours of exposure for optimal effectiveness. Does not cross the placenta in significant amounts, making it safe during pregnancy. May interfere with routine newborn blood typing and direct Coombs testing. Patients should be monitored for hypersensitivity reactions.
Contraindications
Conditions and patient states where this medication should be avoided or used with caution.
Do not use (1)
Known allergy to this medication or its components
Use caution (1)
Consult healthcare provider for benefits vs risks assessment
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 24, 2026. · Read our editorial policy