Rho(D) Immune Globulin
RhoGAM (Rho(D) immune globulin) is a prescription medication containing antibodies against the Rh(D) antigen on red blood cells. It is primarily used to prevent Rh sensitization in Rh-negative mothers who have been exposed to Rh-positive fetal blood, which can occur during pregnancy, delivery, miscarriage, abortion, or certain procedures. By preventing sensitization, it reduces the risk of hemolytic disease of the fetus and newborn in subsequent pregnancies.
RhoGAM prevents Rh-negative mothers from developing antibodies against Rh-positive fetal blood cells, protecting future pregnancies from complications.
Key facts at a glance
- RxNorm
- 204300
- Generic
- Rhogam
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prevention of Rh isoimmunization in Rh-negative women during pregnancy, after miscarriage, ectopic pregnancy, abortion, amniocentesis, chorionic villus sampling, cordocentesis, fetal surgery, trauma, or delivery of an Rh-positive baby. Also used in Rh-negative individuals who received Rh-positive blood transfusions.
Contains anti-Rh(D) antibodies (IgG) that bind to Rh(D)-positive red blood cells, preventing the Rh-negative mother's immune system from recognizing and mounting an immune response against these foreign antigens. This prevents sensitization that could attack future Rh-positive fetuses.
Administered via intramuscular injection, typically at 28 weeks gestation and within 72 hours after delivery or other sensitizing events. Not indicated for Rh-positive individuals or those already sensitized. May cause injection site reactions, fever, or mild allergic reactions. Does not affect the current pregnancy; protects future pregnancies.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy