Ribociclib
Ribociclib is a targeted cancer medication classified as a CDK 4/6 inhibitor, used primarily in combination with hormone therapies to treat certain types of breast cancer. It works by blocking specific proteins that regulate cell division, helping to slow or stop cancer cell growth.
Ribociclib is a CDK 4/6 inhibitor used to treat hormone receptor-positive breast cancer by blocking proteins that drive cancer cell division.
Key facts at a glance
- ATC
- L01EF02
- RxNorm
- 1873916
- Generic
- Ribociclib
- Class
- atc-l01
- Brands
- Kisqali
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Ribociclib is indicated for the treatment of postmenopausal women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer, typically used in combination with an aromatase inhibitor or fulvestrant.
Ribociclib inhibits cyclin-dependent kinase 4 and 6 (CDK 4/6), which are enzymes that regulate the cell cycle. By blocking these kinases, it prevents cancer cells from progressing through the cell cycle, inhibiting tumor growth and proliferation.
Common side effects include neutropenia, fatigue, and liver enzyme elevations. Regular blood monitoring is required during treatment. Ribociclib may cause fetal harm and should not be used during pregnancy. It is taken orally in scheduled cycles.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy