Riluzole
Riluzole is a glutamate inhibitor medication primarily used to treat amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease affecting nerve cells in the brain and spinal cord. By reducing glutamate activity, it helps slow disease progression and modestly extends survival in ALS patients. This medication is typically prescribed when ALS is confirmed or suspected.
Riluzole is a glutamate-inhibiting drug used to slow progression of ALS (Lou Gehrig's disease).
Key facts at a glance
- ATC
- N07XX02
- RxNorm
- 35623
- Generic
- Riluzole
- Class
- atc-n07
- Brands
- Rilutek, Tiglutik, Exservan, Teglutik
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet, suspension
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Riluzole is FDA-approved for the treatment of amyotrophic lateral sclerosis (ALS). It is used to extend survival or delay the need for mechanical ventilation in patients with this condition.
Riluzole works by decreasing glutamate neurotransmitter activity in the brain. It inhibits the release of glutamate and blocks certain voltage-dependent sodium channels, which is believed to reduce excitotoxicity (nerve cell damage caused by excessive glutamate) that contributes to motor neuron degeneration in ALS.
Common side effects may include dizziness, nausea, and liver enzyme elevations. Regular liver function monitoring is recommended during treatment. Riluzole should be taken on an empty stomach, at least one hour before or two hours after meals. Women of childbearing potential should use effective contraception during treatment.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy