Rimantadine
Rimantadine is an antiviral medication historically used for the prevention and treatment of influenza A virus infections in adults and children. It works by interfering with viral replication early in the infection cycle, though its clinical use has declined significantly due to widespread resistance among circulating influenza strains.
Rimantadine is an older antiviral for influenza A that is now rarely used due to high drug resistance.
Key facts at a glance
- ATC
- J05AC02
- RxNorm
- 9386
- Generic
- Rimantadine
- Class
- atc-j05
- Brands
- Flumadine
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- solution, tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Prophylaxis and treatment of influenza A virus infections. Note: Due to widespread resistance, it is no longer recommended as a first-line treatment by CDC and other health authorities.
Mechanism is not fully understood. Appears to act early in viral replication, possibly by inhibiting virus uncoating. Genetic studies suggest involvement of the viral M2 protein in its antiviral activity.
Effectiveness has been significantly compromised by resistance in circulating influenza A strains. May cause CNS side effects including dizziness, headache, and insomnia. Should be used with caution in patients with renal or hepatic impairment. Generally replaced by neuraminidase inhibitors (oseltamivir, zanamivir) for current clinical use.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy