Ripretinib
Ripretinib is a tyrosine kinase inhibitor used to treat adults with gastrointestinal stromal tumors (GIST) who have received prior treatment with multiple other kinase inhibitors. It works by targeting and blocking KIT and PDGFRA proteins, which are often overactive in cancer cells.
Ripretinib is a targeted cancer drug used for advanced GIST after other treatments have failed.
Key facts at a glance
- ATC
- L01EX19
- RxNorm
- 2369389
- Generic
- Ripretinib
- Class
- atc-l01
- Brands
- Qinlock
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Ripretinib is indicated for the treatment of adult patients with advanced gastrointestinal stromal tumors (GIST) who have received prior treatment with three or more kinase inhibitors, including imatinib.
Ripretinib inhibits KIT and PDGFRA receptor tyrosine kinases, including wild-type and mutant forms. By blocking these proteins, it prevents cancer cell growth and division.
Common side effects may include hair changes, fatigue, nausea, abdominal pain, and muscle pain. Patients should be monitored for cardiac effects and skin reactions. Ripretinib may cause fetal harm and should not be used during pregnancy.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy