Ipragliflozin
Rivfloza is a prescription RNAi therapy designed to reduce oxalate production in patients with primary hyperoxaluria type 1 (PH1), a rare genetic disorder causing excessive oxalate buildup that can lead to kidney stones and organ damage. It is administered as a monthly subcutaneous injection and is intended for adults and children weighing at least 40 kg.
Rivfloza is an RNAi therapy that reduces oxalate production in patients with primary hyperoxaluria type 1.
Key facts at a glance
- RxNorm
- 2675305
- Generic
- Rivfloza
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Rivfloza is indicated for the treatment of primary hyperoxaluria type 1 (PH1) in adults and pediatric patients weighing at least 40 kg to reduce urinary and plasma oxalate levels.
Rivfloza contains nedosiran, an RNAi therapeutic agent that specifically targets and inhibits the lactate dehydrogenase (LDH) enzyme in liver cells, which is responsible for converting glyoxylate to oxalate. By blocking this pathway, the medication reduces endogenous oxalate production.
Rivfloza is administered via subcutaneous injection once monthly. Common side effects may include injection site reactions and potential liver enzyme elevations. Patients should be monitored for oxalate levels and kidney function. It is contraindicated in patients with severe renal impairment or on dialysis; dosing adjustments may be needed in patients with mild-to-moderate kidney disease.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy