Rofecoxib
Rofecoxib is a COX-2 selective nonsteroidal anti-inflammatory drug (NSAID) that was used to treat pain and inflammation. It was primarily prescribed for osteoarthritis, rheumatoid arthritis, and acute pain conditions such as menstrual pain. The medication was withdrawn from the global market in 2004 due to an increased risk of serious cardiovascular events.
A COX-2 inhibitor NSAID formerly used for pain relief that was withdrawn from the market due to cardiovascular safety concerns.
Key facts at a glance
- ATC
- M01AH02
- RxNorm
- 232158
- Generic
- Rofecoxib
- Class
- atc-m01
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- suspension, tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Rofecoxib was used to treat osteoarthritis, rheumatoid arthritis, acute pain, and dysmenorrhea (menstrual pain).
As a COX-2 selective inhibitor, rofecoxib blocks the cyclooxygenase-2 enzyme, which is involved in producing prostaglandins that cause pain and inflammation, while sparing COX-1 which protects the stomach lining.
This medication was voluntarily withdrawn from the market in September 2004 due to increased risk of heart attack and stroke. It should not be used by patients with cardiovascular disease, history of stroke, or uncontrolled hypertension. Common side effects included fluid retention, hypertension, and gastrointestinal symptoms.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy