Romiplostim
Romiplostim (Nplate) is a thrombopoietin receptor agonist that stimulates platelet production by binding to and activating the TPO receptor on bone marrow cells. It is primarily used to treat chronic immune thrombocytopenia (ITP) in adult and pediatric patients who have had an insufficient response to other treatments such as corticosteroids, immunoglobulins, or splenectomy.
Romiplostim is an injectable medication that helps increase platelet production in patients with chronic immune thrombocytopenia by mimicking the action of the body's natural thrombopoietin hormone.
Key facts at a glance
- ATC
- B02BX04
- RxNorm
- 805452
- Generic
- Romiplostim
- Class
- atc-b02
- Brands
- Nplate
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- injection
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of chronic immune thrombocytopenia (ITP) in adults and children 1 year and older who have had an inadequate response to corticosteroids, immunoglobulins, or splenectomy.
As a thrombopoietin receptor agonist, romiplostim binds to and activates the TPO receptor on megakaryocyte precursor cells in the bone marrow, stimulating increased platelet production through a mechanism analogous to endogenous thrombopoietin.
Administered as a weekly subcutaneous injection by a healthcare professional. Should not be used to normalize platelet counts. May increase risk of bone marrow reticulin formation and worsening thrombocytopenia after discontinuation. Contraindicated in patients with known hypersensitivity to the product or its components. Regular platelet monitoring is required.
Official drug label
WellAlly may earn a referral fee from linked resources at no extra cost to you. Editorial content is never influenced by commercial relationships.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy