Mesalamine
Rowasa is a prescription rectal enema medication containing mesalamine, an anti-inflammatory agent used to treat inflammatory bowel conditions affecting the lower colon and rectum. It is primarily prescribed for mild to moderate ulcerative colitis to reduce inflammation and help manage symptoms such as rectal bleeding, diarrhea, and abdominal discomfort.
Rowasa is a rectal enema medication containing mesalamine used to treat inflammatory bowel diseases like ulcerative colitis affecting the distal colon.
Key facts at a glance
- RxNorm
- 202834
- Generic
- Rowasa
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Rowasa is indicated for the treatment of mild to moderate distal ulcerative colitis, including proctosigmoiditis and ulcerative proctitis. It is used to reduce symptoms such as rectal bleeding, stool frequency, and inflammation in the lower portions of the colon and rectum.
Mesalamine, the active ingredient in Rowasa, is an aminosalicylate that works locally in the colon to reduce inflammation. Although the exact mechanism is not fully established, it is believed to inhibit inflammatory mediators and reduce leukotriene production in the colonic mucosa, helping to control inflammatory responses.
Rowasa is administered rectally as an enema, typically at bedtime. Patients should follow dosing instructions carefully and use for the full prescribed duration even if symptoms improve. Common side effects may include rectal discomfort, cramping, gas, or mild headache. Rare but serious side effects can include kidney problems and allergic reactions. Patients with a history of kidney disease or sulfa allergy should discuss risks with their healthcare provider.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy