Entrectinib
Rozlytrek (entrectinib) is a targeted cancer therapy known as a TRK inhibitor. It is used to treat adults and children with solid tumors that have a specific genetic alteration called NTRK gene fusion, as well as adults with ROS1-positive non-small cell lung cancer. The medication works by blocking the activity of certain proteins that promote cancer cell growth.
Rozlytrek is a targeted therapy for cancers with NTRK gene fusions or ROS1-positive NSCLC.
Key facts at a glance
- RxNorm
- 2197868
- Generic
- Rozlytrek
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of adults and children (12 years and older) with solid tumors that have NTRK gene fusion, and adults with metastatic ROS1-positive non-small cell lung cancer.
Enters cancer cells and inhibits TRK (tropomyosin receptor kinase) and ROS1 proteins, blocking signals that drive cancer cell growth and survival.
May cause serious side effects including neurological issues, liver problems, heart rhythm abnormalities, and bone fractures. Can harm an unborn baby. Patients should avoid driving if they experience dizziness. Regular monitoring by a healthcare provider is necessary during treatment.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy