Rucaparib
Rucaparib is a poly (ADP-ribose) polymerase (PARP) inhibitor used to treat ovarian cancer, particularly in patients with BRCA gene mutations. It works by blocking enzymes involved in DNA repair, causing cancer cells with damaged DNA to die. This medication is typically used in patients who have responded to prior chemotherapy.
Rucaparib is a PARP inhibitor used to treat ovarian cancer in patients with BRCA mutations by blocking DNA repair in cancer cells.
Key facts at a glance
- ATC
- L01XK03
- RxNorm
- 1862579
- Generic
- Rucaparib
- Class
- atc-l01
- Brands
- Rubraca
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet
- Regions
- US, EU, CN, JP
- Monitoring
- —
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Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of recurrent ovarian cancer in patients who have responded to platinum-based chemotherapy, and for maintenance treatment of ovarian cancer associated with BRCA mutations.
Rucaparib inhibits PARP-1, PARP-2, and PARP-3 enzymes involved in DNA repair. By blocking these enzymes, it prevents cancer cells from repairing damaged DNA, leading to cell death, particularly effective in cells with existing DNA repair defects like BRCA mutations.
May cause serious side effects including bone marrow problems, nausea, fatigue, and liver issues. Regular blood monitoring is required. Contraindicated in pregnancy. Should be taken as prescribed by an oncologist.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy