Conestat Alfa
Ruconest is a recombinant C1 esterase inhibitor used to treat acute hereditary angioedema (HAE) attacks in adults and adolescents. It works by replacing deficient or dysfunctional C1 inhibitor protein, helping to reduce swelling and other symptoms associated with HAE attacks.
Ruconest is a treatment for hereditary angioedema attacks that works by replacing deficient C1 inhibitor protein.
Key facts at a glance
- RxNorm
- 1599837
- Generic
- Ruconest
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Ruconest is indicated for the treatment of acute angioedema attacks in patients with hereditary angioedema (HAE) due to C1 inhibitor deficiency. It is approved for use in adults and adolescents.
Ruconest contains conestat alfa, a recombinant form of human C1 esterase inhibitor. It works by inhibiting the activity of C1 esterase and kallikrein, which are involved in the inflammatory cascade that causes angioedema symptoms. This helps to control swelling and other symptoms during an acute attack.
Ruconest is administered by intravenous injection and should be used under medical supervision. It is not indicated for other forms of angioedema. Patients should discuss their complete medical history with their healthcare provider, including any history of thrombosis or hypersensitivity reactions, before starting treatment. As with all medications, use only as prescribed by a qualified healthcare professional.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy