Rufinamide
Rufinamide is an antiepileptic medication used as adjunctive therapy to treat seizures associated with Lennox-Gastaut syndrome, a severe form of epilepsy. While its precise mechanism is not fully understood, in vitro studies suggest it works primarily by modulating sodium channel activity, particularly by prolonging the inactivation state of these channels, which helps reduce seizure frequency and severity.
Rufinamide is an antiepileptic drug for Lennox-Gastaut syndrome that works by modulating sodium channels to reduce seizures.
Key facts at a glance
- ATC
- N03AF03
- RxNorm
- 69036
- Generic
- Rufinamide
- Class
- atc-n03
- Brands
- Banzel
- Availability
- rx
- Lactation
- unknown
- Routes
- oral
- Forms
- tablet, suspension
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Adjunctive treatment of seizures associated with Lennox-Gastaut syndrome in adults and children. It may also be used for other forms of epilepsy when prescribed by a specialist.
While the exact antiepileptic mechanism is unknown, in vitro studies indicate rufinamide primarily modulates sodium channel activity by prolonging their inactivation state, which helps limit excessive neuronal firing associated with seizures.
Take with food to improve absorption. Common side effects include headache, dizziness, fatigue, and nausea. May require gradual dose titration. Inform your doctor if you have a history of mood disorders or suicidal thoughts, as antiepileptic drugs may increase these risks. Do not stop taking abruptly without medical supervision.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed July 26, 2026. · Read our editorial policy