Fostemsavir
Rukobia is a brand-name antiretroviral medication containing the active ingredient fostemsavir. It is specifically designed for adults with HIV who have difficulty constructing an effective regimen due to resistance or intolerance to multiple antiretroviral medicines. Rukobia works by blocking the initial stage of HIV infection, helping to reduce viral load and improve immune function in patients with limited treatment options.
Rukobia is an HIV attachment inhibitor used for treatment-experienced adults who need new options due to drug resistance.
Key facts at a glance
- RxNorm
- 2380540
- Generic
- Rukobia
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Rukobia is indicated for the treatment of HIV-1 infection in adults with limited treatment options due to resistance, intolerance, or safety considerations. It is used in combination with other antiretroviral medications when a fully suppressive regimen cannot be formed with available agents.
Rukobia is a gp120 attachment inhibitor. It binds to the HIV envelope glycoprotein gp120, blocking the initial attachment of the virus to host CD4+ T-cells. This prevents the conformational changes necessary for viral entry into cells, serving as a first-in-class attachment inhibitor.
Rukobia should be taken twice daily with or without food. The most common side effects include nausea, headache, and fatigue. Patients should be monitored for immune reconstitution syndrome and liver function. Rukobia is not a cure for HIV and must be used as part of a complete antiretroviral regimen. Drug interactions may occur with certain transporters and should be reviewed with a healthcare provider.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy