Amivantamab
Rybrevant (amivantamab) is a prescription bispecific antibody used to treat adults with non-small cell lung cancer that has specific EGFR mutations or exon 20 insertion mutations. It is typically used when the cancer has spread or cannot be removed by surgery. This medication is administered as an intravenous infusion in a healthcare setting.
Rybrevant is a targeted cancer therapy for certain types of advanced non-small cell lung cancer with EGFR mutations.
Key facts at a glance
- RxNorm
- 2729299
- Generic
- Rybrevant Faspro
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Treatment of adults with locally advanced or metastatic non-small cell lung cancer (NSCLC) with EGFR exon 20 insertion mutations, as detected by an FDA-approved test. May also be used for other EGFR-mutated NSCLC after platinum-based chemotherapy has failed.
Rybrevant is a bispecific monoclonal antibody that targets both EGFR and MET receptors on cancer cells. It works by blocking signals that promote cancer cell growth and also recruits immune cells to help destroy the cancer cells.
Administered as an intravenous infusion, typically weekly for the first 4 weeks, then every 2 weeks thereafter. Common side effects include rash, infusion-related reactions, nail problems, and swelling. Patients should be monitored for skin reactions and electrolyte abnormalities. Pre-medication is required to reduce infusion reaction risk.
Official drug label
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy