Midostaurin
Rydapt (midostaurin) is a prescription kinase inhibitor used to treat adults with newly diagnosed acute myeloid leukemia (AML) that has a FLT3 mutation, as well as certain rare blood cell disorders including aggressive systemic mastocytosis, mast cell leukemia, and myeloproliferative neoplasms. It works by blocking specific enzymes involved in cancer cell growth and is typically used in combination with chemotherapy for AML treatment.
Rydapt is a targeted therapy drug for FLT3-positive AML and certain mast cell disorders that works by inhibiting cancer cell growth pathways.
Key facts at a glance
- RxNorm
- 1919089
- Generic
- Rydapt
- Class
- brand-name
- Brands
- —
- Availability
- rx
- Lactation
- unknown
- Routes
- —
- Forms
- —
- Regions
- US, EU, CN, JP
- Monitoring
- —
This page is for informational purposes only.
Do not use this information to diagnose yourself or to replace a physician's advice. Always consult a qualified healthcare provider before starting, stopping, or changing any medication. If you believe you are experiencing a medical emergency, call your local emergency number immediately.
Rydapt is indicated for newly diagnosed FLT3-mutation positive acute myeloid leukemia in adults (used with chemotherapy), as well as for adults with aggressive systemic mastocytosis, mast cell leukemia, or myeloproliferative neoplasms with associated hematological neoplasms.
Midostaurin inhibits multiple receptor tyrosine kinases including FLT3 and KIT, blocking signals that promote the growth and survival of abnormal blood cells and mast cells.
Requires FLT3 mutation testing before use in AML. Should not be used during pregnancy as it can cause fetal harm. Common side effects include fever, nausea, vomiting, and mouth sores. Patients should be monitored for lung symptoms and photosensitivity during treatment.
Official drug label
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 9, 2026. · Read our editorial policy